Why was the study performed? The purpose, which can be both primary and secondary, should be compared with the conclusion.
Is it a prospective or retrospective study? Generally prospective studies are more reliable,since the criteria are set before the patients are treated. Results from randomized controlled trials outweigh non–randomized, larger studies outweigh smaller and blinded studies outweigh open studies.
The method used is of great importance for the outcome of the results. What is the strength in study design and what do previous studies say? Is the used method described well (which is important for reproducing)? What was the length of follow–up?